De Vere’s Grade-II listed property Devonport House in Greenwich is up for sale at a guide price of £22m.
The 100-bedroom property is owned by Richard Upton of U+I, who sold off Eynsham Hall last month to Hoxton Hotel owner Ennismore and now hopes to follow suit with the Greenwich hotel.
Devonport House sits within a UNESCO World Heritage site in Greenwich and dates back to the 18th century.
It was restored in 2011 in a project spearheaded by Upton.
Upton owned a trio of hotels formerly owned by his old company Cathedral Group including Devonport House and Eynsham Hall and has been privately selling off the properties since 2015 when the group merged with Development Securities to form U+I.
The sale of Devonport House also includes a 17th century mausoleum where Sir Admiral Hardy, flag captain to Admiral Lord Nelson, rests and sculptures endowed to Greenwich by Francois Hameury.
Originally designed by Sir Edwin Cooper, the hotel is currently managed by De Vere Group and also contains 14 conference rooms, a restaurant and bar facility.
Upton said: “Following the successful sale of Eynsham Hall to Ennismore, owner of Hoxton hotels and Gleneagles, we have placed Devonport House in the market seeking an owner who can deliver the next chapter of a business success story.”
Last week, Upton sold Eynsham Hall in Oxfordshire for £8.25m to Ennismore, who since completing the acquisition, has announced plans to undertake a refurbishment programme of the 135-bed hotel.